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Paclitaxel is a monomer diterpenoid compound extracted from the bark of Taxus. It is a complex secondary metabolite and the only known drug that can promote microtubule polymerization and stabilize the polymerized microtubule. Isotopic tracing showed that paclitaxel only binds to the polymerized microtubules and does not react with the unpolymerized tubulin dimers. When cells contact paclitaxel, they accumulate a large number of microtubules in cells, which interfere with various functions of cells, especially stop cell division in mitosis and block normal cell division. According to the clinical research of Ⅱ - Ⅲ, paclitaxel is mainly suitable for ovarian cancer and breast cancer, and also has certain curative effect on lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma and brain tumor.
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