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Smetinib, developed by AstraZeneca, UK, is used to treat advanced non-small cell lung cancer. Smetinib inhibits the growth of a variety of tumors, including melanoma with b-raf-mutation and non-small cell lung cancer with K-ras mutation (NSCLC), mainly by regulating the level of key protein kinase MEK in the RA Raf-MEK-ERK pathway. It is mainly used for the treatment of cholangiocarcinoma, colorectal cancer and NSCLC. At present, smetinib is in the phase III clinical trial of non-small cell lung cancer.
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