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Pemetrexed Disodium Hepthydrate
Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy medicine called folate antimetabolites.
It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate
reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). By inhibiting the formation of precursor
purine and pyrimidine nucleotides, pemetrexed prevents the formation of DNA and RNA, which are required for the
growth and survival of both normal cells and cancer cells.
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