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Temozolomide is the first oral effective imidazolium tetrazine anti-tumor drug, which belongs to the second generation of alkylating agents with anti-tumor activity. After oral administration, temozolomide does not need to be activated by metabolism in the liver. It is easy to pass through the blood-brain barrier, has good tolerance and no superimposed toxicity with other drugs. It has synergistic effect with radiotherapy, and is suitable for recurrent malignant glioma after conventional treatment, such as polymorphous gum It is also the first-line treatment for metastatic melanoma.
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