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This drug is a small molecular substance that can inhibit many receptor tyrosine kinases, some of which are involved in the process of tumor growth, pathological angiogenesis and tumor metastasis. By evaluating the activity of sunitinib in inhibiting various kinases (more than 80 kinds of kinases), it is proved that sunitinib can inhibit platelet-derived growth factor receptor, vascular endothelial growth factor receptor, stem cell factor receptor, FMS like tyrosine kinase-3, type 1 colony stimulating factor receptor and neurotrophic factor receptor derived from glial cell line. Biochemical and cellular assays confirmed that sunitinib can inhibit the activity of tyrosine kinase of these receptors, and the inhibition of sunitinib was proved in cell proliferation assay. Biochemical and cellular assays showed that the main metabolites were similar to those of sunitinib.
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