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Toremifene, a chloroethyl derivative of tamoxifene, can competitively bind to estrogen receptor in breast cancer cell plasma, enter the nucleus to regulate the synthesis of mRNA and protein, and prevent the proliferation and differentiation of cancer cells. It is safe to take orally. The peak plasma concentration is reached within 4 hours. The area under the plasma concentration time curve is directly proportional to the dosage. It is mainly metabolized in the liver. Only a small part of the metabolites are excreted from the kidney, and most of them are excreted from the body through defecation. Therefore, hepatoenterocirculation can occur. It has anti estrogen and anti-tumor effects. This product is bound to estrogen receptor, which can prevent the synthesis of chromosomal genes and the growth of tumor cells caused by estrogen. It is suitable for postmenopausal breast cancer and the treatment of recurrent breast cancer. No matter long-term or short-term drug use, there is no obvious toxicity.
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