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Tasigna is a new kind of tumor targeting drug, which belongs to tyrosine kinase inhibitor. It is used to treat CML patients resistant to imatinib, and has a significant effect. Gleevec is a preferred drug developed by Novartis for the treatment of chronic myelogenous leukemia (CML). Nilotinib is improved from the molecular structure of imatinib, which has a stronger selectivity for bcr-abl kinase activity, a stronger inhibition of tyrosine kinase than imatinib by 30 times, and can inhibit the BCR-ABL mutant kinase activity resistant to imatinib. It can also inhibit the activity of kit and PDGFR kinase.
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