366017-09-6
MOSINTER
366017-09-6
Availability: | |
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Payment & Shipping Terms | Supply Capacity | ||
Payment Terms: | T/T, WU | Production Capacity: | 1000kg/year |
Min. Order: | 1 Gram | Packing: | according to the customer's requirements |
Means of Transport: | Ocean, Air, Land | Delivery Date: | 7 days |
Mubritinib
CAS 366017-09-6
Mubritinib (TAK-165) is a potent Neu (HER2) and Cdc2 p34 inhibitor with IC50 of 6 nM and 0.2μM, respectively. TAK 165
alsoinhibits p33cdk2 and p33cdk5. TAK 165 displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src.
TAK 165 exhibits potent antiproliferative effects in Neu-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast
cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth.
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