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Leuprorelin CAS 53714-56-0 LH-RH LEUPROLIDE

Place of Origin:Zhejiang,China (Mainland)
  • 53714-56-0
  • 53714-56-0
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CAS 53714-56-0

Leuprorelin, goserellin, triptoreline and nafrareline are currently commonly used drugs to remove ovaries in the treatment of premenopausal breast cancer and prostate cancer (GnRH-a drugs for short). GnRH-a drugs are similar to GnRH in structure, competing for GnRH receptor in pituitary. When GnRH receptor in pituitary is fully occupied and exhausted by GnRH-a, it will have a downward regulating effect on pituitary, that is, prolapse The decrease of gonadotropins secreted by the body leads to the obvious decrease of sex hormones secreted by the ovary, which is similar to the operation of ovariectomy, which is called drug ovariectomy. Leuprorelin, a GnRH analogue, is a peptide composed of nine amino acids. This product can effectively inhibit the function of pituitary gonadal system. Its resistance to proteolytic enzyme and affinity to GnRH receptor of pituitary are stronger than GnRH. The activity of promoting the release of luteinizing hormone (LH) is about 20 times of GnRH, and its inhibition to pituitary gonadal function is also stronger than GnRH. At the initial stage of treatment, FSH, LH, estrogen or androgen may rise for a short time. Subsequently, FSH, LH and the secretion of estrogen or androgen are inhibited due to the decreased responsiveness of pituitary gland, which has therapeutic effect on sex hormone dependent diseases (such as prostate cancer, endometriosis, etc.).

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