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Irinotecan hydrochloride is a semi synthetic derivative of camptothecin. It is light yellow powder or light yellow crystalline powder at room temperature, odorless. Slightly soluble in water, ethanol or chloroform, insoluble in acetone. Camptothecin can specifically bind to topoisomerase I, which can induce reversible single strand breaks, so that the DNA double strand structure can be untwisted; irinotecan and its active metabolite SN-38 can bind to topoisomerase I-DNA complex, so as to prevent the reconnection of the broken single bond, resulting in cytotoxicity, which is time-dependent and specific to S-phase, and toxicity is also Better than irinotecan. It is suitable for the treatment of patients with advanced colorectal cancer, combined with 5-fluorouracil and folic acid to treat patients with advanced colorectal cancer who have not received chemotherapy before. As a single drug, it is used to treat patients who have failed to receive chemotherapy containing 5-fluorouracil. Irinotecan has broad-spectrum and strong antitumor activity in vivo and in vitro. It is important that irinotecan and its metabolites are still effective in the expression of multidrug-resistant tumors.
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