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Cediranib CAS 288383-20-0 NSC-732208

Place of Origin:Sichuan,China (Mainland)
Brand:MOSINTER
Appearance:Yellowish crystalline powder
Formula:C25H27FN4O3
Mol. mass:450.505 g/mol
Boiling point:626.557°C at 760 mmHg

  • 288383-20-0
  • MOSINTER
  • 288383-20-0
Product Description

Payment & Shipping Terms

Supply Capacity

Payment Terms:

T/T, WU

Production Capacity:

1000kg/year

Min. Order:

1 Gram

Packing:

according to the customer's requirements 

Means of Transport:

Ocean, Air, Land

Delivery Date:

7 days

 

Cediranib

CAS 288383-20-0

Cediranib is an oral antitumor drug. It is a highly effective inhibitor of VEGFR tyrosine kinase and can inhibit all known VEGFR tyrosine kinases (including VEGFR-1, VEGFR-2, VEGFR-3 and PDGFR). Sildenab can inhibit VEGF induced angiogenesis, neovascularization and xenograft cell growth. In the phase I study of NSCLC patients, it was found that the combination of sildenab and PC regimen had significant antitumor effect. Phase II / III study br24 studied 30 mg of sildenab as the first-line treatment for NSCLC patients, which proved that it had antitumor effect, but the incidence of adverse events was high, including diarrhea, dehydration, hand foot syndrome, hypertension and neutropenia. Therefore, it was decided to stop the clinical trial. Repeated evaluation of the dose and toxicity of the combination indicated that part of the adverse reactions were dose-related, and it could be tried to reduce the dose to improve the drug tolerance.

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