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Tetraethyl thiuram disulfide, or dithiolon, is used to treat chronic alcohol addiction because of its immediate response to alcohol. When we drink alcohol (ethanol), ethanol will be converted into acetaldehyde through the action of alcohol dehydrogenase in the liver, acetaldehyde will be converted into acetic acid through the action of acetaldehyde dehydrogenase, and finally acetic acid will be converted into H20 and CO2 through the citric acid circulation to be discharged from the body. However, dithione blocks the conversion of acetaldehyde to acetic acid by inhibiting the action of acetaldehyde dehydrogenase, resulting in acetaldehyde accumulation and physical discomfort, which should be used in cooperation with the doctor's prescription. In addition to alcohol, dithione is also used in cocaine withdrawal therapy because it prevents the breakdown of dopamine.
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