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105 ° (C=0.54, CH2Cl2/Et2O)
Tibolone is a synthetic steroid hormone drug, which is fairly non-selective in its binding profile, acting as an agonist mainly at estrogen receptors, with a preference for ER alpha. It is used mainly for treatment of endometriosis, as well as hormone replacement therapy in post-menopausal women. Tibolone has similar or greater efficacy compared to older hormone replacement medicine, but shares a similar side effect profile. It has also been investigated as a possible treatment for female sexual dysfunction.