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Mifepristone CAS 84371-65-3 Mifepriston Dianhydride

Place of Origin: Shandong,China (Mainland)
Brand: MOSINTER
CAS: 84371-65-3
Density: 1.18g/cm3
Vapour pressure: 1.14E-16mmHg at 25°C
Boiling point: 628.6°C at 760 mmHg
Storage condition: 2-8°C
Flashing point: 334°C

  • 84371-65-3
  • MOSINTER
  • 84371-65-3
Product Description

Payment & Shipping Terms

Supply Capacity

Payment Terms:

T/T, WU

Production Capacity:

500kg/year

Min. Order:

1 Gram

Packing:

according to the customer's requirements 

Means of Transport:

Ocean, Air, Land

Delivery Date:

7 days

 

Mifepristone

CAS: 84371-65-3

Item

Index

Molecular   Formula

C29H35NO2

Molecular weight

429.59

Specification

CP/USP/EP

Melting point

195-198°C

Storage Condition

2-8°C

 

Mifepristone (or RU-486) is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. The compound is a 19-nor steroid with substitutions at positions C11 and C17 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl] 17 alpha-[1-propynyl]estra-4,9-dien-3-one), which antagonizes cortisol action competitively at the receptor level.

Mifepristone can also be used in smaller doses as an emergency contraceptive; if taken after sex but before ovulation, it can prevent ovulation and so prevent pregnancy. In this role, a 10 mg dose is not as effective as the 600 mg dose, but has fewer side-effects. Mifeprex and Mifegyne are only available in 200 mg tablets.

 

A review of studies in humans found that the contraceptive effects of the 10 mg dose were probably due mainly to its effects on ovulation, and not inhibition of implantation, but "the knowledge of the mechanism of action remains incomplete". Treatment with 200 mg of mifepristone changes steroid receptor expression in the fallopian tube, inhibits endometrial development, and effectively prevents implantation.

 

Other uses

Mifepristone is approved for use in theUnited Statesand the EU for the treatment of Cushing's Syndrome via a patented preparation manufactured by Corcept Therapeutics.

Use as a cervical ripening agent has also been described.

 

 

 

 


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