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What is Trifluoroacetic Acid CAS 76-05-1

Views: 3     Author: Site Editor     Publish Time: 29-11-2022      Origin: Site



Melting point: - 15.4℃ (lit.)

Boiling point: 72.4℃ (lit.)

Density: 1.489 g/mL at 20℃ (lit.)

Vapor density: 3.9 (vs air)

Vapor pressure: 97.5 mm Hg (20℃)


CAS 76-05-1


Colorless volatile smoking liquid, similar to acetic acid, with hygroscopic and irritating odor. Influenced by electron absorbing trifluoromethyl, it has strong acidity, which is 100000 times stronger than acetic acid. It is miscible with water, fluorohydrocarbon, methanol, ethanol, ether, acetone, benzene, carbon tetrachloride and hexane, and can partially dissolve carbon disulfide and alkanes above six carbon. It is an excellent solvent for protein and polyester.

Preparation method

Trifluoroacetic acid is an important organic synthesis reagent, which can be used to synthesize various fluorinated compounds, pesticides and dyes. Trifluoroacetic acid is also a catalyst for esterification and condensation; It can also be used as a protective agent of hydroxyl and amino groups for the synthesis of sugars and peptides. There are many preparation routes for trifluoroacetic acid:


1. 3,3,3-trifluoropropene is oxidized by potassium permanganate.

2. Acetic acid (or acetyl chloride and acetic anhydride) is obtained by electrochemical fluorination with hydrofluoric acid, sodium fluoride, etc., and hydrolysis.

3. 1,1,1-trifluoro-2,3,3-trichloropropane is oxidized by potassium permanganate. This raw material can be prepared by Swarts fluorination of hexachloropropylene.

4. It is prepared by oxidation of 2,3-dichlorohexafluoro-2-butene.

5. Trichloroacetonitrile reacts with hydrogen fluoride to form trifluoroacetonitrile, which is obtained by hydrolysis.

6. It is obtained by oxidation of trifluorotoluene.


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