Views: 1 Author: Site Editor Publish Time: 19-05-2022 Origin: Site
Melting point: 177-182℃
Boiling point: 258.15℃ (roughestimate)
Density: 1.3818 (rougheChemicalbookstimate)
Refractive index: 1.6190 (estimate)
Storage conditions: Inertatmosphere, 2-8℃
Dimetridazole, also known as dimezole, this product is off-white or slightly yellow powder, odorless, bitter in taste, gradually turns black when exposed to light, easily soluble in chloroform and ethanol, slightly soluble in water or ether.
Dimetronidazole is effective against protozoa such as Trichomonas blackheads, Trichomonas bovis, Pouch worms, flagellates, as well as bacteria such as necrotizing anaerobes, Clostridium, Staphylococcus anaeobacteria, Enterobacter, Treponema, etc. It has a significant inhibitory effect and is an effective drug for the treatment of turkey blackhead and swine red dysentery. The product can also be used as a growth promoter to promote the production of pigs and chickens and improve the feed conversion rate. When this product is used as a feed additive, it should be premixed with 10-20 times the amount of feed during feed processing, and then evenly mixed with the total amount of feed required. Or mix this product with an appropriate amount of carrier first, then add it to the feed and stir. In the processing of compound feed, pelleting and other operations have no effect on the effect of this product. The product can be mixed into feed, and can also be added to drinking water for livestock and poultry to drink. Metronidazole has low toxicity, is well tolerated by animals, and has no carcinogenic and teratogenic effects. The product is rapidly absorbed in the intestinal tract, distributed in various tissues, and enters the intestinal and hepatic circulation through the biliary tract. In poultry and livestock, it is excreted after oxidation and reduction metabolism. Most of the residues in the carcass were destroyed after 48 hours or after cooking. It also decomposes quickly in the soil, so it will not cause pollution to the environment. The product is stable and can be stored for two years in a dry place below 37°C.
Taking glyoxal as the starting material, cyclized with acetaldehyde and ammonia to obtain 2-methylimidazole (C4H5N2, [693--98-1]). Then nitration to obtain 2-methyl-5-nitroimidazole (C4H6N3O2, [696-23-1]. Finally, methylation with dimethyl sulfate to obtain metronidazole. The intermediate 2-methylimidazole can also be obtained from ethyl acetate. Diamine is cyclized with acetonitrile to obtain 2-methylimidazoline, which is then obtained by adding active nickel to catalyze dehydrogenation.