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What is Dexamethasone CAS 50-02-2

Views:1     Author:Site Editor     Publish Time: 23-12-2021      Origin:Site Inquire

Properties


Melting point: 262-264℃(lit.)

Boiling point: 568.2±50.0℃(Predicted)

Density: 1.1283(estimate)

Refractive index: 76°(C=1,Dioxane)

Flash point: 9℃


50-02-2

CAS 50-02-2



Introduction


It is white or almost white crystal or crystalline powder; odorless, slightly bitter taste. It is easily soluble in acetone, soluble in methanol or absolute ethanol, slightly soluble in ethanol or chloroform, very slightly soluble in ether, and insoluble in water. Its sodium phosphate is easily soluble in water. It is a synthetic adrenal cortex hormone. It is a glucocorticoid anti-inflammatory and anti-allergic drug. Its pharmacological effects are mainly anti-inflammatory, anti-toxic, anti-allergic, and anti-rheumatic, and it is widely used in clinical practice. In recent years, the European Union believes that eating beef containing hormones such as estradiol, progesterone, and medroxyprogesterone can disrupt the normal functions of human endocrine, growth and development, immune system, reproductive system, etc., and may also cause cancer and teratogenesis. The use of these hormones in animals is prohibited.


Uses


It is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates the survival, growth and differentiation of T cells. Dexamethasone inhibits the induction of nitric oxide synthase.


Preparation


A new process for the production of dexamethasone 21-hydroxy compound. The intermediate 21-acetate is used as the substrate, and an appropriate amount of methanol containing 0-10% chloroform is used as a solvent to semi-dissolve the substrate, and a base is used as a catalyst. The hydrolysis reaction is carried out, and after the reaction is completed, the reaction solution is neutralized with acetic acid. The reaction solution is concentrated under reduced pressure to an appropriate volume, cooled, filtered, the filter cake is washed with water, and dried to obtain 21-hydroxyl compound. The process can shorten the production cycle, improve the quality and yield of 21-hydroxyl compounds, and reduce the content of impurities in the 21-hydroxyl compounds.

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