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What is Decitabine CAS 2353-33-5

Views: 1     Author: Site Editor     Publish Time: 08-04-2022      Origin: Site Inquire

Properties


Melting point: ~200℃(dec.)

Boiling point: 370.01℃(roughestimate)

Density: 1.3771 (roughestimate)

Refractive index: 1.6590 (estimate)

2353-33-5

CAS 2353-33-5


Introduction


It is a natural 2′-deoxycytidine analog of adenosine, which inhibits the proliferation of tumor cells and prevents the occurrence of drug resistance by inhibiting DNA methyltransferase and reducing DNA methylation. The specific inhibitor of DNA methylation belongs to the S phase cell cycle specific drug, which is suitable for the treatment of myelodysplastic syndrome (MDS).


Uses


It is an epigenetic modifier that inhibits DNA transmethylase activity, leading to demethylation (hypomethylation) in DNA and activation of genes by remodeling "open" chromatin; when demethylation is associated with When histone acetylation acts in combination, genes can be activated synergistically; 5′-azadeoxycytosine causes DNA demethylation or hemi-demethylation; DNA demethylation can regulate gene expression by "opening" chromatin Detectable structures increase nuclease sensitivity, which remodels chromatin structure, allowing transcription factors to link gene promoter regions, transcription complex assembly, and gene expression.


Adverse reactions


1. Neutropenia (symptoms), thrombocytopenia (symptoms), anemia, vomiting, fatigue, fever, cough, nausea, constipation, diarrhea, hyperglycemia, febrile neutropenia (symptoms).

2. Large doses can cause neurotoxicity, manifested as drowsiness, aphasia, hemiplegia, etc., but can return to normal after drug withdrawal.

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