It is a natural 2′-deoxycytidine analog of adenosine, which inhibits the proliferation of tumor cells and prevents the occurrence of drug resistance by inhibiting DNA methyltransferase and reducing DNA methylation. The specific inhibitor of DNA methylation belongs to the S phase cell cycle specific drug, which is suitable for the treatment of myelodysplastic syndrome (MDS).
Uses
It is an epigenetic modifier that inhibits DNA transmethylase activity, leading to demethylation (hypomethylation) in DNA and activation of genes by remodeling "open" chromatin; when demethylation is associated with When histone acetylation acts in combination, genes can be activated synergistically; 5′-azadeoxycytosine causes DNA demethylation or hemi-demethylation; DNA demethylation can regulate gene expression by "opening" chromatin Detectable structures increase nuclease sensitivity, which remodels chromatin structure, allowing transcription factors to link gene promoter regions, transcription complex assembly, and gene expression.
MOSINTER GROUP was established in 2004. The main office is located in Ningbo, China. The production are located in Zhejiang Province, Jiangsu Province and Shandong Province in China. Specializing in the production and marketing of chemical products, MOSINTER GROUP has excellent production equipment and a high-performing sales team as well as advanced manufacturing technique, comprehensive quality management system and modernized testing methods.
