Views: 1 Author: Site Editor Publish Time: 16-06-2022 Origin: Site
Melting point: 208-210℃
Density: 1.2561 (rough estimate)
Refractive index: 1.6740 (estimate)
Storage conditions: 2-8℃
Albendazole, white to pale yellow crystalline powder, odorless, melting point 208～210℃, insoluble in water, slightly soluble in hot dilute hydrochloric acid, acetone or chloroform, soluble in methanol, ethanol or acetic acid. It is a broad-spectrum thiabendazole anthelmintic, which can be used for both human and veterinary purposes. It can inhibit the growth and reproduction of worms. By inhibiting the intestinal or absorbing proteins of the worms, the worms cannot be Ingestion of sugars for survival will deplete the endogenous glycogen in the worms, inhibit the fumarate reductase system, and prevent the production of adenosine triphosphate, so that the worms cannot survive and reproduce, and eventually the worms die due to energy depletion.
This product is a high-efficiency, broad-spectrum anthelmintic new drug, which has significant efficacy against Fasciola hepatica, tapeworm, lung and gastrointestinal nematodes. It is one of the most powerful benzimidazoles and is currently the first choice for the prevention and treatment of parasitic diseases of livestock and poultry. The product is effective against Fasciola hepatica adults and larvae of cattle and sheep, and Fasciola hepatica, and the reduction rate can reach 90-100%. In recent years, it has been found that this product also has a strong effect on bovine cysticercosis. After treatment, the cysticercosis decreases and the lesions disappear. In addition, the product can also be used to prevent parasitic infection, so it can achieve good results in promoting sheep growth and increasing wool production.
(1) 2-acetamido-4-chloronitrobenzene is used as the starting material, reacts with propanethiol to obtain 2-amino-4-propylthionitrobenzene, and is reduced by palladium carbon to obtain-2amino-4 - Propylthioaniline. Then, it is cyclized with methyl cyanamide to obtain propylthiobenzimidazole.
(2) Take o-nitroaniline as the starting material, react with sodium thiocyanate to obtain 2-nitro-4-thiocyanoaniline, and then react with bromopropane to obtain 2-nitro-4-propylthio Aniline is reduced to 2-amino-4-propylthioaniline by sodium sulfide, and it is directly cyclized with methyl cyanamide to obtain propylthiobenzimidazole without separation. The total yield is 60%.
(3) Using carbendazim as raw material, react with sodium sulfide cyanate to obtain methyl cyano-benzimidazole-2-carbamate, and the yield is 90%. Then carry out a reduction reaction without separation, and directly condense it with bromopropane to obtain a yield of 94%. Or react carbendazim with cyanosulfonic acid to obtain 5-sulfonyl chloride-benzimidazole-2-carbamic acid methyl ester with a yield of 93%. Then use iron powder (zinc powder) to reduce to methyl 2-mercapto-2 benzimidazole-2-carbamate, and then react with bromopropane to obtain.