Place of Origin: Zhejiang,China (Mainland)
Molecular Formula: C12H14N4O2S
Molecular Weight: 278.33
Synonyms : (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin
Melting point: 197 °C
storage temp.: 2-8°C
Water Solubility: 150mg/100mL (29 ºC)
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Sulfamethazine is an antibacterial. Sulfamethazine blocks the synthesis of dihydrofolic acid by inhibiting dihydropteroate synthase. In addition, sulfamethazine is a structural analog and competitive antagonist of para-aminobenzoic acid (PABA) and can inhibit normal bacterial utilization of PABA for the synthesis of folic acid, which is an important metabolite in DNA synthesis.
Functions & Applications:
1.An antibacterial sulfa drugs; induce CYP3A4 expression, as well as through N- acetyltransferase acetylation; exhibit dependence of pharmacokinetics, metabolic changes produced by the male-specific isoforms CYP2C11; inhibiting dihydrofolate synthase, reach hinder the effect of folic acid synthesis. And sulfadiazine equivalent effect. Useful in the treatment of hemolytic streptococcus, meningococcal, pneumococcal and other infectious diseases, lasting effect.
2.As a feed additive for the prevention of staphylococcal and streptococcal infections, etc., that is the main treatment for fowl cholera, fowl typhoid, coccidiosis and so on.
For the prevention and treatment of staphylococcus and streptococcus infections solubility of hemolytic streptococcus bacteria and other bacteria and pleurisy inhibition, the main treatment fowl cholera, fowl typhoid, coccidiosis, etc.
3.As antibacterial agents for the prevention and treatment of staphylococcal and streptococcal infections, etc., for the treatment of hemolytic streptococcus, meningococcus, pneumococcus and other infections.
4.For the treatment of fowl cholera, fowl typhoid, coccidiosis and so on.
Sultamicillin is indicated for infections caused by susceptible micro-organisms. Typical indications are upper respiratory tract infections including sinusitis, otitis media and tonsillitis; lower respiratory tract infections including bacterial pneumonias and bronchitis; urinary tract infections and pyelonephritis; skin and soft tissue infections; intra-abdominal infections and gonococcal infections.
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