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Isoniazid CAS 54-85-3 Isonicotinic Acid Hydrazide

Place of Origin: Zhejiang,China (Mainland)
Molecular Formul: C6H7N3O2
Molecular Weight: 153.1387
CAS NO.: 54-85-3
Melting point: 170-174℃
EINECS: 200-214-6
Fp: >250°C
Refractive index: 1.577
Water solubility: 14 g/100 mL (25℃)

  • 54-85-3
  • MOSINTER
  • 54-85-3
Product Description

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Supply   Capacity

Payment   Terms:

T/T, WU

Production   Capacity:

1000kg/year

Min.   Order:

1 Gram

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According to the customer's requirements 

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Ocean, Air, Land

Delivery   Date:

7 days

 

Isoniazid

CAS 54-85-3

Isoniazid is an antibacterial agent used primarily as a tuberculostatic. Target: Antibacterial Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing.

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