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Polymyxin B Sulphate CAS 1405-20-5 Mastimyxin

Place of Origin: Zhejiang,China (Mainland)
CAS No.: 1405-20-5
Molecular Formul: C48H84N16O17S
Molecular Weight: 1189.3426
Boiling point: 1611°C at 760 mmHg
Melting point: 217-220°C (dec.)
Flash point: 928.1°C
Storage Condition: 2-8°C
Vapour Pressur: 0mmHg at 25°C
Water solubility: 50 mg/mL
  • 1405-20-5
  • 1405-20-5
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Polymyxin B Sulphate

CAS 1405-20-5

Polymyxin B Sulphate is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa. Polymyxin B is composed of a number of related compounds (see "Mixture composition"). It has a bactericidal action against almost all Gram-negative bacilli except the Proteus and Neisseria genera. Polymyxins bind to the cell membrane and alter its structure, making it more permeable. The resulting water uptake leads to cell death. Polymyxins are cationic, basic peptides that act like detergents (surfactants). Side effects include neurotoxicity and acute renal tubular necrosis. Polymyxins are used in the topical first-aid preparation Neosporin.

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