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Meglumine CAS 6284-40-8

Views:2     Author:Site Editor     Publish Time: 10-12-2021      Origin:Site Inquire

Properties


Melting point: 129-131.5℃ (lit.)

Specific rotation: -16.5 º (c=10, H2O, on dry sub)

Boiling point: 331.88℃ (rough estimate)

Density: 1.2669 (rough estimate)

6284-40-8

CAS 6284-40-8



Introduction


It is particularly important for meglumine to choose a suitable counter ion for the drug to improve the solubility and bioavailability of the drug. Meglumine is a counterion widely used to improve the solubility of drugs. It is an amino sugar derived from sorbitol with a pKa value of 9.6. White crystalline powder. Melting point 128-129°C. It is easily soluble in water, slightly soluble in ethanol (in 100ml of ethanol, 1.2g at 25°C and 21g at 70°C), almost insoluble in chloroform. The taste is slightly sweet and salty.


Uses


1. As a co-solvent and surfactant of contrast agent.

2. Diagnostic drugs, as a co-solvent for contrast agents

3. Diagnostic drugs, co-solvents and surfactants for contrast agents

4. Biochemical research


Production method


It is obtained by catalytic hydrogenation after the condensation of glucose and monomethylamine. Add anhydrous ethanol and dry glucose to the reaction pot, and pass in dry monomethylamine gas at 50°C. After reaction for 1.5-2h, the solution gradually becomes clear. Keep at 50°C for 2h to obtain a glucose methylamine solution. Then put it into the autoclave, in the presence of Reynolds nickel, pressurize to 2.5MPa with hydrogen, and stir for 1-2h at 80-85°C. Then the material is discharged after cooling and pressure relief, the upper meglumine ethanol solution is cooled and crystallized, filtered to obtain crude meglumine, and then refined to obtain the finished product.


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