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Palbociclib, a new breast cancer drug developed by Pfizer in the United States, is marketed as IBRANCE, an oral cyclin-dependent kinase (CDKs) 4 and 6 inhibitor, the first cyclin-dependent kinase 4/6 (cdk4/6) inhibitor approved by the us FDA. CDKs4 and 6 are key regulators of cell cycle and can trigger cell cycle progression. IBRANCE is indicated in the United States for the combination of letrozole for the treatment of estrogen receptor-positive, and human epidermal growth factor receptor-negative (ER+/ her2-negative) postmenopausal advanced breast cancer patients, as an initial endocrine-based regimen for the treatment of metastatic diseases.
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