Guanoxan Sulfate CAS 5714-04-5

Guanoxam (CAS: 5714-04-5)

Methods of Manufacturing

REACTION OF 6-AMINO-4-CHLORO-N'-METHYL-M-BENZENEDISULFONAMIDE WITH THE DIMETHYL ACETAL OF 2,2,2-TRIFLUOROETHYLMERCAPTOACETALDEHYDE IN ETHYLENE GLYCOL DIMETHYL ETHER IN THE PRESENCE OF A CATALYST

5-Chloroaniline-2,4-disulfonamide + 2,2,2-trifluoroethanol + mercaptoacetaldehyde (sulfide formation/carbonyl condensation/methylation).

Biomedical Effects and Toxicity

Pharmacological Action

Medicine used in the treatment of acute or chronic vascular HYPERTENSIONregardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.