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Pimecrolimus CAS 137071-32-0 ASM 981

Place of Origin: Zhejiang,China (Mainland)
Name: Pimecrolimus
CAS: 137071-32-0
Molecular Formula: C43H68ClNO11
Molecular Weight: 810.459
Brand: MOSINTER
Content: 98%min
Synonyms 1: ASM 981
Synonyms 2: SDZ-ASM 981
storage temp: -20°C
density: 1.19

  • 137071-32-0
  • MOSINTER
  • 137071-32-0
Product Description

Payment & Shipping Terms

Supply Capacity

Payment Terms:

T/T, WU

Production Capacity:

500T/year

Min. Order:

1 Gram

Packing:

according to the customer's requirements 

Means of Transport:

Ocean, Air, Land

Delivery Date:

7 days

 

Pimecrolimus

CAS: 137071-32-0

ASM 981  SDZ-ASM 981

Topical immunomodulators

Pimecrolimus is a topical immunomodulators and is a kind of semi-synthetic products of the Streptomyces-produced ascomycin. It has a greater lipophilicity than tacrolimus with a stronger affinity with the skin. It can effectively and safely control the signs and symptoms of facial seborrheic dermatitis and can quickly relieve the itching symptoms of patients with dermatitis and eczema as well as reduce the lesion area, clear atopic dermatitis (eczema) sign. Therefore, it is an effective treatment method for the treatment of atopic dermatitis (eczema) for both early remission purpose and long-term control purpose. 

 

Chemical Properties:White Solid

Usage: Pimecrolimus is a semi-synthetic, macrocyclic lactone derived from ascomycin by activation of the 32-hydroxy group with a triflate ester, and nucleophilic substitution with chloride under phase transfer conditions to provide the chloro analogue. Pimecrolimus has been targeted for treatment of inflammatory skin disorders. Like all tacrolimus analogues, pimecrolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Pimecrolimus is extensively cited in the literature with over 2,000 citations.

 

 


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