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Irbesartan is a Angiotensin Ⅱ receptor inhibitors.Angiotensin Ⅱ receptor divides into two kinds,AT1 and AT2.Irbesartan can inhibit AngⅠ to transform into AngⅡ by blocking the AT1 receptor of AnglI selectively,It can also antagonism AT1 specifically.Antagonism between the AT1 is AT2 8500 times.By blocking the combination of AngⅡ and AT1,it can inhibit vascular contraction and the release of aldosterone,then lower the blood pressure.
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