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Calcitonin Salmon CAS 47931-85-1 Manufacturer in China
Calcitonin salmon is an hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Calcitonin decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. Alternative splicing of the calcitonin pre-mRNA can yield a mRNA encoding calcitonin gene-related peptide; that peptide appears to function in the nervous and vascular systems. The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.
Molecular formula ingredients: salmon peptide synthesis material
Pharmacokinetic The editor One hour after muscle and subcutaneous injection, maximum blood drug concentration, the half-life of 70-90 minutes, absolute bioavailability in about 70%. This product and metabolites of renal excretion by 95%, 2% to prototype discharge, 0.15 0.31 / kg, the apparent volume of distribution type protein accounts for 30-40%.
Dosage and administration:
Subcutaneous or intramuscular injection, once a day, every time 50 ~ 100 iu a day or 100 iu, and adequate intake of calcium and vitamin D, according to the needs of the individual in case of progressive loss of bone. In the treatment of hypercalcemia: daily per kilogram of body weight 5 ~ 10 iu, one or two times subcutaneous or intramuscular injection. Treatment of deformation osteitis: subcutaneous or intramuscular injection, daily or every other day 100 iu.
Matters need attention:
Calcitonin allergies, pregnant women and nursing mothers are prohibited. 1, before clinical use, skin test must be conducted: use t.b take 0.2 ml syringe, not diluted with physiological salt to 1 ml, subcutaneous injection of 0.1 ml (about 1 unit), watch 15 minutes, should be no more than moderate red negative. 2 patients treated, long-term lie in bed, every month need to check the blood biochemistry and renal function. 3, there is no experience with children. 4, deformation osteitis and has a history of fractures in patients with chronic disease, according to the serum alkaline phosphatase and urinary hydroxyproline discharge decided to stop or continue to treatment.
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