Isotretinoin (CAS: 4759-48-2) is a vitamin A-type medicine.
Isotretinoin Attribute
Molecular Formula | C20H27O2 |
Molecular Weight | 299.4277 |
Melting point | 174-177℃ |
Boiling point | 462.8°C at 760 mmHg |
Flash point | 350.6°C |
Water solubility | insoluble |
Vapour Pressur | 7.55E-10mmHg at 25°C |

Isotretinoin Molecular Formula
Synonyms: 13-cis-retinoic acid; 13-cis-vitamin a acid; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid; (13cis)-15-oxidoretinal
It is a vitamin A-type medicine, there is a strong and quick suppression function of the skin gland cells proliferation and differentiation processes, severe nodular cystic acne efficient. This product is better absorbed by the stomach, and topical invalid. Other medicine used to treat severe acne ineffective, cystic acne, acne party, rosacea, ichthyosis, follicular keratosis and other skin disorders pityriasis red hair have a certain effect.
Isotretinoin (INN), also known as 13-cis retinoic acid, is an oral pharmaceutical medicine primarily used to treat cystic acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne medicine.
Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a transient worsening of acne (lasting 2–3 weeks), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn. Uncommon and rare side effects include: muscle aches and pains (myalgias), and headaches. Isotretinoin is known to cause birth defects due to in utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development.
Women taking isotretinoin must not get pregnant during, and for 1 month after isotretinoin therapy. Sexual abstinence, or effective contraception is mandatory during this period. Barrier methods by themselves (such as condoms) are not considered adequate due to the unacceptable failure rates of approximately 3%. Women who fall pregnant whilst on isotretinoin therapy are generally counselled to have a termination. Isotretinoin has no effect on male reproduction.
Isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments. Acne treatment usually begins with topical retinoids (e.g., tretinoin, adapalene), in combination with topical antibiotics (e.g., clindamycin, erythromycin) or antiseptics (e.g., benzoyl peroxide-containing preparations), followed by oral antibiotics (e.g., doxycycline or minocycline). In women a cyproterone acetate-containing contraceptive pill can be useful if there are no contraindications.
In cases of hormonal acne, such as in women in their 20s and 30s with cyclical acne, often a course of isotretinoin can permanently improve acne obviating the need for lifelong hormonal manipulation.
Standard: USP28 EDMF (DMF NO.19191)
Assay: ≥99%

Appearance: Orange red flakes powder

Packing: 5kg/tin