Benzbromarone (CAS: 3562-84-3) is a uricosuric agent
R22:Harmful if swallowed.;
S36:Wear suitable protective clothing.;
Benzbromarone Molecular Formula
Synonyms: 3,5-dibromo-4-hydroxyphenyl-2-ethylbenzo[b]furan-3-yl ketone
Benzbromarone (INN) is a uricosuric agent and non-competitive inhibitor of xanthine oxidase used in the treatment of gout, especially when allopurinol, a first-line treatment, fails or produces intolerable adverse effects. It is structurally related to the antiarrhythmic amiodarone.
Benzbromarone is highly effective and well tolerated, and clinical trials have suggested it is superior to both allopurinol, a xanthine oxidase inhibitor but not uricosuric, and probenecid, another uricosuric medicine
Effect on cytochrome P450
Benzbromarone is a very potent inhibitor of CYP2C9. Several analogues of the medicine have been developed as CYP2C9 and CYP2C19 inhibitors for use in research.
Adverse reactions: diarrhea, stomach discomfort, nausea and other symptoms of digestive system; urticaria, rash, redness, itching and other skin allergies; abnormal liver function and aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase increased.
Occasionally, the gastrointestinal discomfort, such as nausea, vomiting, stomach fullness and diarrhea and other phenomena.
Rarely appear urticaria (rubella).
In individual circumstances, it will also show an inflammation of the conjunctiva (Jie Moyan), a short time of impotence, the abnormal part of skin eczema (Pi Zhen), headache and urinary frequency increase.
In some circumstances, it is even more to see if the liver has been exacerbated by the hepatitis B virus.
This disease has some acute outbreak, it is difficult to grasp.
According to reports, taking benzbromarone itching, facial redness, erythema, hypersensitivity, edema, pit of the stomach discomfort adverse reactions occur.
According to the national adverse drug reaction monitoring database analysis, the problem of liver damage in severe adverse reactions of benzene and Malone was more prominent. The majority of medical personnel, pharmaceutical production, business enterprises and the public should be aware of the risk of liver damage in benzene, Malone, in the use of benzene bromide Malone should start with the use of small doses, to avoid the use of other medicine with liver toxicity, should be regularly monitored during the treatment of liver function.
1, to any of the ingredients in this product allergy.
2, moderate to severe renal utility (glomerular filtration rate lower than 20ml/min) and patients with kidney stones.
3, pregnant women, pregnant women and lactating women disabled.
1 persistent diarrhea should be discontinued.
2 can not be taken in the acute attack of gout, because the beginning of the treatment phase, with the tissue in the acid digestion, it may aggravate the disease.
3 in order to avoid the early treatment of acute episode of gout, suggestions combined with colchicine or anti-inflammatory medicine in the initial administration.
4 during the treatment, a large number of drinking water in order to increase the amount of urine (early treatment of drinking water volume of not less than 1.5-2 liters), so as not to be excreted in the urine uric acid caused by excessive uric acid crystallization. Regular measurement of urine pH value, in order to promote the alkalinization of urine, as appropriate, given sodium bicarbonate or citric acid mixture, and pay attention to acid-base balance, urine pH should be regulated in 6.2 to 6.8.
5 at the beginning of treatment, a large number of uric acid excreted with urine, so at this time, the dosage should be small (starting dose).
6 long-term medication, should be regularly checked liver function.
7 should avoid the use of medicine for other liver damage.
Appearance: white crystalline powder
Packing: 25KG drum