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|Payment Terms:||L/C, T/T, WU||Production Capacity:||50 Kilogram/Year|
|Min. Order:||1 Gram||Packing:||According to the...|
|Means of Transport:||Ocean, Air, Land||Delivery Date:||within 7 days|
Saquinavir Mesylate CAS: 149845-06-7
1015°C at 760 mmHg
0mmHg at 25°C
In HIV infected cells, HIV protease specifically cleaved the viral precursor protein, so that the infected virus particles could eventually form. These viral precursor proteins exist in the presence of the decomposition site, can only be HIV and its closely related to the virus protease recognition. Shah Que Bernard Vee is a kind of peptide, which simulates this type of decomposition site. Therefore, saquinavir and HIV-1 and 2 protease active site just can be closely combined with in vitro showed reversible and selective inhibition of protease activity, rather than the affinity of human protease about 50000 times lower.
Different from nucleoside analogues (Zidorf, etc.), Shah Que Bernard Vee has a direct effect on viral target enzymes, which are not required to be activated by metabolic activation, and also have a potential role in resting cells. In 10-10 mol / L concentration, saquinavir on lymphoblastoid cell lines and single nuclear cell lines and laboratory strains and clinical isolates of HIV-1 infected lymphocytes and monocytes to start training effect.
Laboratory of cell culture results showed that saquinavir and other reverse transcriptase inhibitors (including AZT (zidovudine), DDC (zalcitabine), DDI (didanosine) are two couplet or triple therapy of HIV1 infection, there are additional synergistic antiviral effect, but without increasing toxicity.
Category: Antibiotic Drugs API