Resorcinol CAS 108-46-3 3-Hydroxyphenol nakotgg pelagolrs m-Benzenediol

Place of Origin: Zhejiang,China (Mainland)
Appearance: White needle crystal
Melting point: 108℃
Boiling point: 280.8℃
Flash point: 127℃
Molecular weight: 110.1106
Relative density: 1.2717
Molecular formula: C6H6O2
Characteristic: Harmful
Assay: ≥99%
Solubility: Soluble in water, ethanol, amyl alcohol

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Product Description

Payment & Shipping Terms Supply Capacity
Unit Price:5951.0 USDPacking:25KG Plastic woven bag
Payment Terms:T/T, WUDelivery Date:within 7 days
Min. Order:1 Ton

General description

Resorcinol has bactericidal, fungicidal and anti-itching effect with the bactericidal effect being 1/3 of the phenol and also a low irritating and corrosive property. At low concentration, it can play the role promoting the regeneration of horny while having keratin exfoliation effect at high concentration. It is mainly used for rubber adhesives, plastics, synthetic resins, synthetic fibers, dyes, preservatives, anti-itch, anti-fungal agent, analytical reagent and can also be used to treat ringworm, eczema, seborrheic dermatitis, acne and psoriasis.

Chemical Properties

The chemical property of resorcinol is active and it can participate in the following four kinds of reaction.  
(1) It can have reaction with sodium amalgam, water for production of dihydro-resorcinol (1, 3-cyclohexanedione).

(2) It can generate ester with reaction with acid anhydride.

(3) It can react with hydroxylamine in a diketone type to generate oxime.

(4) In the action of concentrated sulfuric acid or zinc chloride, it can react with phthalic anhydride to generate fluorescent dye-fluorescent yellow.


Pharmacological effects

In a concentration of 1% to 2%, it has antiseptic, bactericidal, fungicidal, astringent, antipruritic and horny promoting effect. At a concentration between 5% and 20%, it has keratolytic effect and can cause the exfoliation of stratum corneum. At a concentration of 40%, it has corrosive effect. It can be absorbed through the skin or ulcers surface.

Indications

It can be used for the treatment of seborrheic dermatitis, acne, superficial skin fungal infections, tinea versicolor, calluses, corns, and common warts.

Adverse reactions

1, it can cause contact dermatitis and has weak irritation effect on skin and mucous membrane. This product, when being absorbed through broken skin and wound surface in the large amount, can lead to myxedema.  
2, because this product can be absorbed through the skin or ulcers, and thus is not suitable or being applied to nfants and young children in high concentration and large-scale.
3, poisoning symptoms include diarrhea, nausea, vomiting, stomach pain, dizziness, severe or persistent headache, fatigue or weakness, being prone to excitement or irritability, sleepiness, sweating, bradycardia, and shortness of breath.
4, applying this product to the wound of children can lead to methaemoglobinaemia.
5, since this product has anti-thyroid effects, systemic effects is similar as phenol poisoning, but often accompanied with convulsions.

Precautions

1, it can turn pale hair to black color; it can cause skin redness and scaling at a few days after treatment; take this drug with caution.
2, dark-skinned patients may be caused by its stimulation of pigment generation.
3, when being used in combination with soaps, cleansers, acne preparations, preparations containing alcohol or acid-dimensional A, it can cause skin irritation or excessive drying effect.
4, it has anti-thyroid effects; it can lead to myxedema upon long term use (especially used in ulcer surface).
5. This product is toxic and thus this product can't subject to systemic or long-term use; avoid applying it to the broken skin wound in order to preventing poisoning.

Test methods

Current ways for determination of resorcinol include spectrophotometry, fluorescence kinetics, high performance liquid chromatography, and capillary electrophoresis method.

Application

1. It can be used as the raw materials for the production of synthetic resins, adhesives, dyes and ultraviolet absorbing agent. It can also be used as the dipped cord of tire. Medically it can be used as the disinfection antiseptic agent.
2. Resorcinol is also known as 1, 3-hydroquinone. In the field of pesticides, it can be used as the intermediate 3-chloro-4-methyl coumarin and herbicide oxyfluorfen in the synthesis of pesticides coumaphos. It can also be used for the production of dyes, specialty coatings, pharmaceuticals, photographic material, synthetic resins, adhesives, and cosmetics.
3. Resorcinol is mainly used for the field of rubber adhesives, synthetic resins, dyes, preservative, pharmaceutical and analytical reagents. Resorcinol is similar with phenol and cresol. It can generate condensation polymer through the reaction with formaldehyde. It can be used for making glue silk and the adhesive agent of tire cord for nylon-purpose, making wood glue, and being as the adhesive for vinyl material and metal. Resorcinol is the intermediate of many kinds of azo dyes and fur dyes as well as the raw material of pharmaceutical intermediates, p-nitrogen salicylic acid. Resorcinol has bactericidal effects and can be used as preservatives for being supplied to cosmetics and dermatological medicine pastes and ointments. The resorcinol derivatives, β-methylumbelliferone can be used as the intermediate for optical bleach; tri-nitro resorcinol is detonator. There is also a considerable amount of resorcinol being used in the production of benzophenone-class ultraviolet absorbers. This product can irritate the skin and mucous membranes, can cause poisoning disease through the rapid absorption by the skin. Minimum lethal dose of rat being subject to subcutaneous injection is 450mg / kg.
4. It can be applied to the fields of photographic film, medicines, dyes and chemical fiber industry.
5. It can also be used as reagents for analysis.
6. It can be used for characterization and determination of zinc, lead, tartaric acid, nitrate and nitrite through colorimetric method; it can also applied to the colorimetric reaction for measuring sugar and Furfuryl alcohol; as the reagent for detecting ketone sugars and lignin; it can also applied to the salt reagent of diazonium compound as well as to organic synthesis.

Production method

Benzene sulfonic acid is sulfonated with oleum; further go through neutralization, alkaline melting, acidification, n-butanol extraction, evaporation of the solvent, and distillation to obtain the finished products. 2. It can be produced through the hydrogenation of m-dinitrobenzene into m-phenylenediamine which is further subject to hydrolysis to get the finished product. 3. It can be produced from the hydrolysis of m-aminophenol. Resorcinol can also derived from benzene and propylene using peroxide di-isopropylbenzene method with the process being similar as isopropylbenzene production.
Put benzene, 65% fuming sulfuric acid and sodium sulfate separately into the reactor; control the reaction temperature at 75 ℃ to obtain the sulphonate. Then add anhydrous sodium sulfate to this sulphonate, stir and heat to 175 ℃ for dissolving it; Add sulfur trioxide at this temperature and continue the reaction for an additional 1.5h to generate di-sulphonate (with the content of benzene disulfonic acid being 75%). Use dilute alkali to neutralize the di-sulphonate and remove the excess amount of sulfate salt; the resulting sodium benzene di-sulfonate is gradually added into the molten sodium hydroxide 290 °C; raise the temperature to 325 °C within 15min and further dissolve the alkali melting substance in water; acidify it with sulfuric acid and extract with ether; evaporate the solvent to obtain the finished resorcinol products

Health Hazard

Inhalation of vapors or dust causes irritation of respiratory tract.  Ingestion causes burns of mucous membranes, severe diarrhea, pallor, sweating, weakness, headache, dizziness, tinnitus, shock, and severe convulsions; may also cause siderosis of the spleen and tubular injury to the kidney.  Contact with eyes causes irritation. Can be absorbed from wounds or through unbroken skin, producing severe dermatitis, methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea, and death.



ITEM
INDEX
RESULT
Content of resorcinol(HPLC)%
≥99.799.8
Content of hydroquinone(HPLC)%≤0.05
0.005
Content of phenol(HPLC)%≤0.1ND
Content of pyrocatechol(HPLC)%≤0.1ND
Crystallization Point▫C≥109110



Category: Other Chemical Products


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