Oxaliplatin CAS 61825-94-3 63121-00-6 latin xalatoplatinum ι-OHP RP-54780

Model: MOSINTER
Place of Origin: Shandong,China (Mainland)
Molecular Formula: C6H14N2.C2O4.Pt
Specification: CP/USP/EP
Molecular Weight: 397.29

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Oxaliplatin (CAS: 63121-00-6)


Item

Index

Molecular Formula

C6H14N2.C2O4.Pt

Molecular Weight

397.29

Specification

CP/USP/EP

Oxaliplatin (pronounced ox-ally-plat-in), marketed as Eloxatin by Sanofi, is a platinum-based antineoplastic agent used in cancer chemotherapy.

History

Oxaliplatin was discovered in 1976 at Nagoya  City University by Professor Yoshinori Kidani, who was granted U.S. Patent 4,169,846 in 1979. Oxaliplatin was subsequently in-licensed by Debiopharm and developed as an advanced colorectal cancer treatment. Debio licensed the drug to Sanofi-Aventis in 1994. It gained European approval in 1996 (initially inFrance) and approval by the U.S. Food and Drug Administration in 2002. Generic oxaliplatin was first approved in theUnited Statesin August 2009. In 2010, Sanofi regained exclusivity protection for the drug until August 2012.

Structure and mechanism

The compound features a square planar platinum(II) center. In contrast to cisplatin and carboplatin, oxaliplatin features the bidentate ligand 1,2-diaminocyclohexane in place of the two monodentate ammine ligands. It also features a bidentate oxalate group.

According to in vivo studies, oxaliplatin fights carcinoma of the colon through non-targeted cytotoxic effects. Like other platinum compounds, its cytotoxicity is thought to result from inhibition of DNA synthesis in cancer cells. In particular, oxaliplatin forms both inter- and intra-strand cross links in DNA, which prevent DNA replication and transcription, causing cell death.

Clinical use

Oxaliplatin is used for treatment of colorectal cancer, typically along with folinic acid and fluorouracil in a combination known as FOLFOX. Oxaliplatin has been compared with other platinum compounds used for advanced cancers, such as cisplatin and carboplatin.

Advanced colorectal cancer

In clinical studies, oxaliplatin by itself has modest activity against advanced colorectal cancer. When compared with just fluorouracil and folinic acid administered according to the de Gramont regimen, a FOLFOX4 regime produced no significant increase in overall survival, but did produce an improvement in progression-free survival, the primary end-point of the phase III randomized trial.

Adjuvant treatment of colorectal cancer

After the curative resection of colorectal cancer, chemotherapy based on fluorouracil and folinic acid reduces the risk of relapse. The benefit is clinically relevant when cancer has spread to locoregional lymph nodes (stage III, Dukes C). The addition of oxaliplatin improves relapse-free survival, but data on overall survival have not yet been published in extenso.

When cancer has not spread to the locoregional lymph nodes (stage II, Dukes B) the benefit of chemotherapy is marginal and the decision on whether to give adjuvant chemotherapy should be carefully evaluated by discussing with the patient the realistic benefits and the possible toxic side effects of treatment. This is even more relevant when the oncologist proposes treatment with oxaliplatin.

Adverse effects

Side-effects of oxaliplatin treatment can potentially include:

•     Neurotoxicity leading to chemotherapy-induced peripheral neuropathy, a progressive, enduring and often irreversible tingling numbness, intense pain and hypersensitivity to cold, beginning in the hands and feet and sometimes involving the arms and legs, often with deficits in proprioception.[8]

•     Fatigue

•     Nausea, vomiting, or diarrhea

•     Neutropenia (low number of a type of white blood cells)

•     Ototoxicity (hearing loss)

•     Extravasation if oxaliplatin leaks from the infusion vein it may cause severe damage to the connective tissues.

•     Hypokalemia (low blood potassium), which is more common in women than men

In addition, some patients may experience an allergic reaction to platinum-containing medicine. This is more common in women.

Oxaliplatin has less ototoxicity and nephrotoxicity than cisplatin and carboplatin.

Category: Antineoplastic Drugs API

Related Category: Other Pharmaceutical API  Veterinary Medicine API  Diagnostic Agents API  Vitamin Preparation API  Psychotropic Drugs API 


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