Gimeracil CAS 103766-25-2 GIMERACIL gimestat

Place of Origin: Zhejiang,China (Mainland)
Brand: MOSINTER
CAS: 103766-25-2
Appearance: White crystal powder
Purity %≥: 99
Molecular Weight: 145.54
Molecular Formula: C5H4ClNO2
Specification: CP/USP/EP

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Product Description

Payment & Shipping Terms Supply Capacity
Payment Terms:L/C, T/T, WUProduction Capacity:200KGS / YEAR
Min. Order:10 KilogramPacking:As per request of...
Means of Transport:Ocean, Air, LandDelivery Date:within 7 days

Gimeracil (CAS: 103766-25-2)


Item

Index

Molecular Formula

C5H4ClNO2

Molecular Weight

145.54

Specification

CP/USP/EP

Content

≥99%


The combination drug tegafur/gimeracil/oteracil (trade name Teysuno) is used for the treatment of advanced gastric cancer. It is also being developed for the treatment of hepatocellular carcinoma.

Mechanism of action

Tegafur is the actual chemotherapeutic agent. It is a prodrug of the active substance fluorouracil (5-FU).

Gimeracil inhibits the degradation of fluorouracil by reversibly blocking a dehydrogenase enzyme. This results in higher 5-FU levels and a prolonged half-life of the substance.

Oteracil mainly stays in the gut because of its low permeability, where it reduces the production of 5-FU by blocking the enzyme orotate phosphoribosyltransferase. Lower 5-FU levels in the gut result in a lower gastrointestinal toxicity.

Category: Antineoplastic Drugs API

Related Category: Other Pharmaceutical API  Veterinary Medicine API  Diagnostic Agents API  Vitamin Preparation API  Psychotropic Drugs API 


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