Fenbendazole CAS 43210-67-9 HOE-881V

Place of Origin: Zhejiang,China (Mainland)
CAS: 43210-67-9
Molecular formula: C15H13N3O2S
Melting point: 233℃
Refractive index: 1.709
Molecular weight: 299.3476
Density: 1.4g/cm3

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Product Description

Payment & Shipping Terms Supply Capacity
Payment Terms:L/C, T/T, WUProduction Capacity:100Ton/year
Min. Order:50 KilogramPacking:As per request of...
Means of Transport:Ocean, Air, LandDelivery Date:within 7 days

Fenbendazole (CAS 43210-67-9)


ITEM

STANDARD

RESULT

Appearance

White or almost white powder

White powder

Identification

Comp1ics with spcctrum of Fcnbcndazo1c CRS

Complies

Total impurities

≤ 1.0%

0.3%

Impurity A

≤ 0.5%

< 0.05%

Impurity B

≤ 0.5%

< 0.05%

Any other impurity

≤ 0.5%

0.21%

Loss on drying

≤ 1.0%

0.1%

Heavy metals

≤ 20 ppm

< 20 ppm

Sulphated ash

≤ 0.3%

0.1%

Assay (on dried basis)

98.0% ~ 101.0%

100.4%



Fenbendazole (Hoechst brand names Panacur and Safe-Guard, Intervet Panacur and Panacur Rabbit) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms (but not effective against Dipylidium caninum, a common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides and can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Drug interactions may occur if salicylanilides like dibromsalan and niclosamide are co-adminstered. Abortions in cattle and death in sheep have been reported.


Toxicity

Despite being widely used as a dewormer in many species, toxicity has been reported. Birds (storks, pink pelicans, vultures, pigeons and doves) and reptiles (vipers, turtles and tortoises) have shown toxicity associated with bone marrow suppression, intestinal crypt cell necrosis and distal villi sloughing.[citation needed] Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents.


Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The LD50 in laboratory animals exceeds 10 g/kg when administered orally.


Synthesis


Fenbendazole synthesis

Metabolism

It gets metabolized in the liver to oxfendazole, which is anthelmintic too; oxfendazole partially gets reduced back to fenbendazole in the liver and rumen. Also, fenbendazole itself is an active metabolite of another anthelmintic drug, febantel.


Appearance: White or almost white powder

Package: 25KG Drum or As per request of clients

Category: Veterinary Medicine API

Related Category: Antibiotic Drugs API  Antineoplastic Drugs API  Heart And Cerebral Vessels API  Hot anti-cancer medicines  Pharmaceutical Intermediates 


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