Enramycin CAS 12772-37-1 11115-82-5 Enduracidin Enradin Enramicina Enramycinum Enramycinum enduracidin hydrochloride

Place of Origin: Zhejiang,China (Mainland)
CAS: 12772-37-1; 11115-82-5
Melting Point: 234~238℃
Synonyms: enduracidin hydrochloride; Enduracidin; Enradin; Enramicina; Enramycinum; Enramycinum
Loss on drying, %: ≤ 10
Assay, %: As the standard of 90.0~110.
pH: 5.0~8.0
Arsenic, ppm: ≤ 4
Heavy metals, ppm: ≤ 20

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Product Description

Payment & Shipping Terms Supply Capacity
Payment Terms:L/C, T/T, WUProduction Capacity:100Ton/year
Min. Order:50 KilogramPacking:As per request of...
Means of Transport:Ocean, Air, LandDelivery Date:within 7 days

Enramycin (CAS: 12772-37-1; 11115-82-5)


ITEM

SPECIFICATION

INDEX

Appearance

Gray or beige powder, Have a special foul-smelling

Comform

Identification

HPLC: The main peak retention time a sample solution and standard solution main peak retention time should be consistent

Comform

particle size

Min.100% pass through 850um

Min.70% pass through 180um

95%

Loss on drying, %

≤ 10

5.5

pH

5.0~8.0

6.3

Heavy metals, ppm

≤ 20

< 20

Arsenic, ppm

≤ 4

< 4

Assay, %

As the standard of 90.0~110.0

102.3(8.18%)



Enramycin or Enduracidin is a polypeptide antibiotic produced by Streptomyces fungicidus. Enramycin is widely used as a feed additive for pigs and chickens to prevent necrotic enteritis induced by Gram-positive gut pathogens.


Mechanism of action

Enramycin acts as an inhibitor of the enzyme, MurG, which is essential for cell wall biosynthesis in Gram-positive bacteria. MurG catalyzes the transglycosylation reaction in the last step of peptidoglycan biosynthesis. Inhibiting this step greatly compromises cell wall integrity leading to cell lysis.


Spectrum of susceptibility

Enramycin has been found to be very effective against Gram-positive gut pathogens, most notably, Clostridium perfringens; a leading cause of necrotic enteritis. The following represents MIC data for a couple of veterinary pathogens.


Clostridium perfringens: 0.05 μg/ml – 1.6 μg/ml

Staphylococcus aureus: 0.013 μg/ml – 0.413 μg/ml


Composition

Standard grade enramycin is composed of two main components called enramycin A and enramycin B. These two components are routinely used as analytical reference standards; however, their activity as individual compounds does not appear to be widely studied or characterized.


Appearance: Gray or beige powder, Have a special foul-smelling

Package: 25KG Drum or As per request of clients

Category: Veterinary Medicine API

Related Category: Antibiotic Drugs API  Antineoplastic Drugs API  Heart And Cerebral Vessels API  Hot anti-cancer medicines  Pharmaceutical Intermediates 


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