Doramapimod CAS 285983-48-4 Doramapimod DoraMapin BIBR796

Place of Origin: Shandong,China (Mainland)
Brand: MOSINTER
Molecular formula: C31H37N5O3
Molecular weight: 527.66
Boiling point: 631.6°C at 760 mmHg
Density: 1.2g/cm3
Flashing point: 335.8°C
Vapour pressure: 7.36E-16mmHg at 25°C

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Product Description

Payment & Shipping Terms Supply Capacity
Payment Terms:L/C, T/T, WUProduction Capacity:5 KG/Year
Min. Order:1 GramPacking:According to the...
Means of Transport:Ocean, Air, LandDelivery Date:within 7 days

Doramapimod(CAS: 285983-48-4)


Item

Index

Molecular Formula

C31H37N5O3

Molecular Weight

527.66

Specification

CP/USP/EP

Content

98%


BIRB796 (Doramapimod) is a pyrazole-based allosteric inhibitor of p38 MAP Kinase with a Kd of 0.1 nM. BIRB796 has slow binding kinetics, as evidenced by an marked increase in apparent IC50 after preincubation periods up to 2h, as well as dissociation rates of up to six orders of magnitude greater when compared to other MAPK inhibitors. BIRB796 possesses an excellent selectivity profile over a panel of relevant kinases, with the most active being inhibition of JNK2a2 at 100 nM (330-fold selectivity).
Related studies have shown that BIRB796 also inhibits activity and activation of SAPK3/p38g (3% remaining activity at 10 uM). At these concentrations, BIRB796 blocks stress-induced phosphorylation of scaffold protein SAP97. 

Category: Antineoplastic Drugs API

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