Citalopram hydrobromide CAS 59729-32-7 Citalopram Hydrobromide Tablets

Model: MOS 21
Place of Origin: Zhejiang,China (Mainland)
Name: Citalopram hydrobromide
CAS: 59729-32-7
Molecular Formula: C20H22BrFN2O
Molecular Weight: 405.3
Content: 98%min
Brand: MOSINTER
Synonyms 1: 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3
Synonyms 3: Citalopram Hydrobromide Tablets
Melting point: 182-188°C
storage temp: -20°C Freezer

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Product Description

Payment & Shipping Terms Supply Capacity
Trade Term:FOB,CIF,DDPProduction Capacity:200KG/MONTH
Payment Terms:L/C, T/T, WUPacking:As per request of...
Min. Order:1 KilogramDelivery Date:within 7 days
Means of Transport:Ocean, Air, Land

Citalopram hydrobromide

CAS: 59729-32-7

Abstract

Citalopram hydrobromide (citalopram HBr) is an orally administered selective serotonin reuptake inhibitor (SSRI) with a chemical structure unrelated to that of other SSRIs or of tricyclic, tetracyclic, or other available antidepressant agents. 
Citalopram HBr occurs as a fine, white to off-white powder. Citalopram HBr is sparingly soluble in water and soluble in ethanol.
The tablet is available as the brand-name drug Celexa. In Australia, the UK, Germany, Portugal, Poland, and most European countries, it is licensed for depressive episodes and panic disorder with or without agoraphobia. In Spain, it is also used for obsessive-compulsive disorder.

Chemical Properties

White Crystalline Powder

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Citalopram (brand names: Celexa, Cipramil and others) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class. It has U.S. Food and Drug Administration approval to treat major depression, which it received in 1998, and is prescribed off-label for other conditions. In Australia, the UK, Germany, Portugal, Poland, and most European countries, it is licensed for depressive episodes and panic disorder with or withoutagoraphobia. In Spain and Denmark it is also used for obsessive-compulsive disorder.


Sexual dysfunction is often a side effect with SSRIs. Specifically, common side effects include difficulty becoming aroused, lack of interest in sex, andanorgasmia (trouble achieving orgasm). One study showed, however, when remission of major depressive disorder is achieved, quality of life and sexual satisfaction is reported to be higher in spite of sexual side effects.

Citalopram theoretically causes side effects by increasing the concentration of serotonin in other parts of the body (e.g., the intestines). Other side effects, such as increased apathy and emotional flattening, may be caused by the decrease in dopamine release associated with increased serotonin. Citalopram is also a mild antihistamine, which may be responsible for some of its sedating properties.

Common side effects of citalopram include drowsiness, insomnia, nausea, weight changes (usually weight gain), increase in appetite, vivid dreaming, frequent urination, decreased sex drive, anorgasmia, dry mouth,increased sweating, trembling, diarrhea, excessive yawning, severe tinnitus, and fatigue. Less common side effects include bruxism, vomiting, cardiac arrhythmia, blood pressure changes, dilated pupils, anxiety, mood swings, headache, and dizziness. Rare side effects include convulsions, hallucinations, severe allergic reactions and photosensitivity. If sedation occurs, the dose may be taken at bedtime rather than in the morning. Some data suggest citalopram may cause nightmares.

Withdrawal symptoms can occur when this medicine is suddenly stopped, such as paraesthesiae, sleeping problems (difficulty sleeping and intense dreams), feeling dizzy, agitated or anxious, nausea, vomiting, tremors, confusion, sweating, headache, diarrhea, palpitations, changes in emotions, irritability, and eye or eyesight problems. Treatment with citalopram should be reduced gradually when treatment is finished.

Citalopram and other SSRIs can induce a mixed state, especially in those with undiagnosed bipolar disorder.


Category: Psychotropic Drugs API

Related Category: Digestive System Drugs API  Circulatory System Drugs API  Insect Repellent API  Antibiotic Drugs API  Antineoplastic Drugs API 


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