Benzophenone CAS 119-61-9 Diphenylmethanone Benzoylbenzene α-Oxodiphenylmethane

Place of Origin: Sichuan,China (Mainland)
Brand Name: MOSINTER
CAS No.: 119-61-9
Molecular formula: C13H10O
Molar mass: 182.22 g/mol
Density: 1.11 g/cm3
Boiling point: 305.4 °C
Melting point: 48.5 °C (119.3 °F; 321.6 K)
Vapor density: 4.21 (vs air)
Refractive index: 1.5893
Vapour pressure: 1 mm Hg ( 108 °C)
Flashing point: >230 °F


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Benzophenone (CAS: 119-61-9)





White crystal



Melting point

47-51 °C(lit.)

Boiling point

305 °C(lit.)

Flash point

>230 °F

Refractive index


Basic Information

Benzophenone is the organic compound with the formula (C6H5)2CO, generally abbreviated Ph2CO. Benzophenone is a widely used building block in organic chemistry, being the parent diarylketone.


Benzophenone can be used as a photo initiator in UV-curing applications such as inks, imaging, and clear coatings in the printing industry. Benzophenone prevents ultraviolet (UV) light from damaging scents and colors in products such as perfumes and soaps. It can also be added to the plastic packaging as a UV blocker. Its use allows manufacturers to package the product in clear glass or plastic. Without it, opaque or dark packaging would be required.

In biological applications, benzophenones have been used extensively as photophysical probes to identify and map peptide–protein interactions.


Benzophenone can be prepared by the reaction of benzene with carbon tetrachloride followed by hydrolysis of the resulting diphenyldichloromethane, or by Friedel-Crafts acylation of benzene with benzoyl chloride in the presence of a Lewis acid (e.g. aluminium chloride) catalyst. The industrial synthesis relies on the copper-catalyzed oxidation of diphenylmethane with air.

Organic chemistry

Benzophenone is a common photosensitizer in photochemistry. It crosses from the S1 state into the triplet state with nearly 100% yield. The resulting diradical will abstract a hydrogen atom from a suitable hydrogen donor to form a ketyl radical.

Benzophenone radical anion

Main article: Air-free technique

Alkali metals reduce benzophenone to the deeply blue colored radical anion, diphenylketyl:

M + Ph2CO → M+Ph2CO·−

Generally sodium is used as the alkali metal. Although inferior in safety and effectiveness relative to molecular sieves, this ketyl is used in the purification of organic solvents, particularly ethers, because it reacts with water and oxygen to give non-volatile products. The ketyl is soluble in the organic solvent being dried, so it accelerates the reaction of the sodium with water and oxygen. In comparison, sodium is insoluble, and its heterogeneous reaction is much slower. When excess alkali metal is present a second reduction may occur, resulting in a color transformation from deep blue to purple:

M + M+Ph2CO·− → (M+)2(Ph2CO)2-

Commercially significant derivatives

Substituted benzophenones such as oxybenzone and dioxybenzone are used in some sunscreens. The use of benzophenone-derivatives which structurally resemble a strong photosensitizer has been strongly criticized (see sunscreen controversy).

Michler's ketone has dimethylamino substituents at each para position.

The high-strength polymer PEEK is prepared from derivatives of benzophenone.

Pharmacological activity of Benzophenone analogs

Benzophenone derivatives are known to be pharmacologically active molecules against various pathological conditions, like anti-tumor, anti-inflammatory and anti-angiogenic activity. One of the benzophenone analogs, was found to inhibit angiogenesis, thereby preventing angiogenesis-dependent disorders, such as mammary carcinoma and rheumatoid arthritis, where it down-regulated the Vascular endothelial growth factor (VEGF) gene expression responsible for angiogenesis.

Benzophenone tagged with coumarin have showed significant reduction in tumour – growth in both Dalton's Lymphoma, and murine ascites carcinoma, by inducing DNA degradation, leading to apoptosis, and by inhibiting angiogenesis. Recent study reports that, benzophenone tagged with benzimidazolehave showed an, enormous tumor inhibiting activity with more than 90% inhibition in murine carcinoma which is due to the down regulation of neo-vessel formation. Moreover this activity was found to increase with methoxy and number of methyl groups which played an important role in the biological activity of the compound.


Category: Cosmetic Ingredient Chemicals

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