Azelaic acid (CAS: 123-99-9)
White to light yellow needle powder
Synonyms: Nonanedioic acid; Azelaicacidtech; Azalaic Acid; Heptane-1,7-dicarboxylic acid; nonanedioate.
Azelaic acid is an organic compound with the formula (CH2)7(CO2H)2. This saturateddicarboxylic acid exists as a white powder. It is found in wheat, rye, and barley. It is a component of a number of hair and skin conditioners.
In plants, azelaic acid serves as a "distress flare" involved in defense responses after infection. It serves as a signal that induces the accumulation of salicylic acid, an important component of a plant's defensive response.
Polymers and related materials
Esters of this dicarboxylic acid find applications in lubrication and plasticizers. With hexamethylenediamine azelaic acid forms Nylon-6,9, which finds specialized uses as a plastic.
Azelaic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne. It belongs to a class of medication called dicarboxylic acids. It works by killing acne bacteria that infect skin pores. It also decreases the production of keratin, which is a natural substance that promotes the growth of acne bacteria Azelaic acid is also used as a topical gel treatment for rosacea, due to its ability to reduce inflammation. It clears the bumps and swelling caused by Rosacea. Azelaic acid has been used for treatment of skin pigmentation including melasma and post inflammatory hyperpigmentation, particularly in those with darker skin types. It has been recommended as an alternative to hydroquinone(HQ). As a tyrosinase inhibitor, azelaic acid reduces synthesis of melanin.
AzClear Action (20% lotion, Ego Pharmaceuticals), Azelex (20% cream, Allergan), White Action cream (20% cream,2% glycolic acid), SynCare), Finacea (15% gel, Intendis/Berlex Laboratories, subsidiaries of Bayer AG), Finevin (20% cream, Intendis/Berlex Laboratories), Skinoren (20% cream or 15% gel, Intendis), Melazepam, Strata Dermatologics, 2oz, Mixed Dicarboxylic Acids 20% Azelaic Acid Cream.,and Azaclear (azelaic acid and niacinamide, Epikinetics LLC).